In most, five more teleost paralogs was identified, as well as 2 of them paralogs demonstrably as a consequence of larger chromosomal duplications
Even more gene duplications when you look at the teleosts
I and see evidence for additional teleost-certain ohnologs in the GATA123 origin, however about GATA456 origin equal to an additional bullet out-of genome replication on the bottom from teleost seafood. So it facts comes from both overlaying this new species phylogeny towards gene phylogeny (evaluate Profile step one to figure 3) to get most 3R copies, however, far more conclusively on evaluations out of continued paralogons.
The fresh new topology your molecular phylogenetic study (Contour 3a) means an effective teleost-wider replication of the GATA2 gene with the separate GATA2a and you can GATA2b genes, probably via the latest 3R teleost-certain genome replication knowledge. As the topology regarding zebrafish GATA2b in the tree is actually a little out of, possibly simply because of its a lot of time part indicating its derived series, the presence of spared syntenic family genes between your tetrapod GATA2 paralogon in addition to teleost GATA2a and you can GATA2b paralogons highly suggests that these types of continued thru a good chromosomal replication.
New zebrafish genome also contains the second GATA1 backup that appears to help you result from the latest 3R replication. Even in the event just used in zebrafish, all of our phylogenetic data shows that this GATA gene possess lead throughout the 3R replication, and you will is secondarily forgotten at the beginning of the newest predecessor of all other teleost. ادامه مطلب