Whether or not a lot of molybdoenzymes are well recognized structurally and you may functionally, evolutionary analyses out of Mo application try restricted
Conceptual
Brand new shade feature molybdenum (Mo) is utilized in many life forms, and it is a key component of many minerals working in nitrogen, sulfur, and you may carbon metabolism . With the exception of nitrogenase, Mo is bound when you look at the necessary protein in order to a great pterin, ergo developing the brand new molybdenum cofactor (Moco) during the catalytic web sites off molybdoenzymes. Right here, i accomplished comparative genomic and you may phylogenetic analyses to examine the newest density and you will progression away from Mo utilization in germs, archaea and you may eukaryotes at the level of (i) Mo transportation and you can Moco utilization trait, and (ii) Mo-dependent nutrients. The show revealed that extremely prokaryotes and all sorts of highest eukaryotes need Mo while of several unicellular eukaryotes together with parasites and most yeasts lost the capability to utilize this metal. Likewise, eukaryotes have a lot fewer molybdoenzyme families than simply prokaryotes. Dimethylsulfoxide reductase (DMSOR) and you will sulfite oxidase (SO) family was indeed the most common molybdoenzymes within the prokaryotes and you may eukaryotes, correspondingly. ادامه مطلب